CXCL12 Inhibition Prevents Telomere Shortening and Repression of Telomerase Activity in Both Early and Late Post-menopausal Atherosclerosis via ABCA1 Upregulation

Telomere shortening, atherosclerosis, and metabolic syndrome.

This mechanism resembles inflammatory reactions to exogenous factors and the wound healing process (2). Dysfunction of vascular endothelial cells is thought to induce a cascade of pathologic reactions of cell groups mediated by the expression of adhesion molecules, resulting in infiltration of mononuclear cells, foam cell formation, promotion of thrombus formation, and disturbed relaxation of b...

telomerase activity and telomere length in aml-m3 patients

introduction: the telomeric dna together with its associated  proteins protects the chromosome ends from degradation or aberrant recombination. telomerase and telomere are closely associated with  development of cancers. in this study we aim to investigate the significance of telomerase activity (ta) and telomere length (tl) in patients with acute promyelocytic leukemia (apl). methods: peripher...

Telomere structure and shortening in telomerase-deficient Trypanosoma brucei

Telomerase consists of a reverse transcriptase (TERT) and an RNA that contains a template for telomere-repeat extension. Telomerase is required to prevent telomere erosion and its activity or lack thereof is important for tumorigenesis and ageing. Telomerase has been identified in numerous organisms but it has not been studied in kinetoplastid protozoa. Trypanosoma brucei, the causative agent o...

Length Shortening T Cell Renewal Rates , Telomerase , and Telomere

T cell renewal rates, telomerase, and telomere length shortening.

Measurements on the average telomere lengths of normal human naive and memory T cells suggested that 1) naive and memory human T cells have similar division rates, and 2) that the difference between naive and memory cells reflects the degree of clonal expansion during normal immune reactions. Here we develop mathematic models describing how the population average of telomere length depends on t...